Auswahl nach Jahren:

2010-2014 2006-2009 2002-2005 1998-2001 1994-1997 1984-1993

Alle Publikationen

86) C. Pöhner, V. Ullmann, R. Hilpert, E. Samain, C. Unverzagt, „Chemoselective coupling of sugar oximes and a-ketoacids to glycosyl amides and N-glycopeptides“ Tetrahedron Lett.  2014, 55, 2197-2200. 

85) A. Reif, S. Siebenhaar, A. Tröster, M. Schmälzlein, C. Lechner, P. Velisetty, K. Gottwald, C. Pöhner, I. Boos, V. Schubert, S. Rose-John, C. Unverzagt, „Semisynthesis of Biologically Active Glycoforms of the Human Cytokine Interleukin 6“ Angew. Chem. 2014, 126, 12321 –12327, Angew. Chem. Int. Ed. 2014, 53, 12125 –12131

84) A. Canales, A. Mallagaray, J. Pérez-Castells, I. Boos, C. Unverzagt, S. André, H.-J. Gabius, F. J. Cañada, J. Jiménez-Barbero* „Breaking Pseudo-Symmetry in Multiantennary Complex N-Glycans Using Lanthanide-Binding Tags and NMR Pseudo-Contact Shifts“ Angew. Chem. Int. Ed. 2013, 52, 13789-13793.

83) C. Unverzagt, Y. Kajihara, „Chemical assembly of N-glycoproteins: a refined toolbox to address a ubiquitous posttranslational modification” Chem. Soc. Rev., 2013, 42, 4408-4420.

82) A. Ardá, P. Blasco, D. Varón Silva, V. Schubert, S. André, M. Bruix, F. J. Cañada, H.-J. Gabius, C. Unverzagt, J. Jiménez-Barbero „Molecular Recognition of Complex-Type Biantennary N‑Glycans by Protein Receptors: a Three-Dimensional View on Epitope Selection by NMR“ J. Am. Chem. Soc. 2013 135, 2667-2675.

81) V. Ullmann, M. Rädisch, I. Boos, J. Freund, C. Pöhner, S. Schwarzinger, C. Unverzagt, “Convergent Solid Phase Synthesis of N-Glycopeptides supported by Pseudoprolines at Consensus Ser/Thr Residues” Angew. Chem. Int. Ed. 2012, 51, 11566-11570.

80) D. Ott, J. Seifert, I. Prahl, M. Niemietz, J. Hoffman, J. Guder, M. Mönnich, C. Unverzagt “Modular Synthesis of Core Fucosylated N-Glycans” Eur. J. Org. Chem. 2012, 5054-5068.

79) R. G. Benevides, G. Ganne, R. da Conceição Simões, V. Schubert, M. Niemietz, C. Unverzagt, V. Chazalet, C. Breton, A. Varrot, B. Sousa Cavada, A. Imberty „A lectin from Platypodium elegans with unusual specificity and affinity for asymmetric complex N-glycans“ J. Biol. Chem 2012, 287, 26352-26364.

78) N. Bovin, P. Obukhova, N. Shilova, E. Rapoport, I. Popova, M. Navakouski, C. Unverzagt, M. Vuskovic, M. Huflejt, „Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?“ Biochim. Biophys. Acta 2012, 1820, 1373-82.

77) M. Niemietz, L. Perkams, J. Hoffman, S. Eller, C. Unverzagt, „Selective Oxidative Debenzylation of Mono- and Oligosaccharides in the Presence of Azides“ Chem. Commun. 2011, 47, 10485 – 10487.

76) C. Heinlein, D. Varón Silva, A. Tröster, J. Schmidt, A. Gross C. Unverzagt, „Fragment condensation of C-terminal pseudoproline peptides without racemization on the solid phase“Angew. Chem. 2011, 123, 6530 –6534; Angew. Chem. Int. Ed. 2011, 50, 6406–6410.

75) M. Veelders, Stefan Brückner, Dimitri Ott, Carlo Unverzagt, H.-U. Mösch, and L.-O. Essen, „ Structural basis of flocculin-mediated social behavior in yeast“ Proc. Natl. Acad. Sci. U S A. 2010, 107, 22511-22516.

74) S. Mezzato, C. Unverzagt „Synthesis of an Fmoc-Asn-heptasaccharide building block and its application to chemoenzymatic glycopeptide synthesis“ Carbohydr. Res. 2010, 345, 1306-1315.

73) J. J. Hernández-Gay, A. Ardá, S. Eller, S. Mezzato, B. R. Leeflang, C. Unverzagt, F. J. Cañada, J. Jiménez-Barbero „Insights into the Dynamics and Molecular Recognition Features of Glycopeptides by Protein Receptors. The three-dimensional Solution Structure of Hevein bound to the Trisaccharide core of N-Glycoproteins“ Chem. Eur. J., 2010, 16, 10715-10726.

72) S. Eller, C. Raps, M. Niemietz, C. Unverzagt „ Convenient introduction of a bisecting GlcNAc residue into multiantennary N-glycans as the ultimate residue“ Tetrahedron Lett. 2010, 51, 2648-2651

71) C. Unverzagt, G. Gundel, S. Eller, R. Schuberth, J. Seifert, H. Weiss, M. Niemietz, M. Pischl, C. Raps „Synthesis of Multiantennary Complex Type N-Glycans by Use of Modular Building Blocks“ Chem. Eur. J., 2009, 15, 12292-12302

70) S. André, T. Kozár, S. Kojima, C. Unverzagt and H.-J. Gabius „From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans“ Biol. Chem. 2009, 390, 557–565

69) C. Piontek, D. Varón Silva, C. Heinlein, C. Pöhner, S. Mezzato, P. Ring, A. Martin, F. X. Schmid and C. Unverzagt, Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C Part 2, Angew. Chem. Int. Ed., 2009, 121, 1974-1978. DOI: 10.1002/anie.200804735

68) C. Piontek, P. Ring, O. Harjes, C. Heinlein, S. Mezzato, N. Lombana, C. Pöhner, Markus Püttner, D. Varón Silva, A. Martin, F. X. Schmid and C. Unverzagt, Semisynthesis of a Homogeneous Glycoprotein Enzyme: Ribonuclease C Part 1, Angew. Chem. Int. Ed., 2009, 48, 1936-1940. DOI: 10.1002/anie.200804734

67) S. Ryczek, K. Dettner, C. Unverzagt, Synthesis of buprestins D, E, F, G and H- structural confirmation and biological testing of acyl glucoses from jewel beetles (Coleoptera: Buprestidae), Bioorg. Med. Chem., 2009, 17, 1187-1192

66) J.-P. Gourdine, G. Cioci, L. Miguet, C. Unverzagt, D. Varón Silva, A. Varrot, C. Gautier, E. J. Smith-Ravin, and A. Imberty, High Affinity Interaction between a Bivalve C-type Lectin and a Biantennary Complex-type N-Glycan Revealed by Crystallography and Microcalorimetry, J. Biol. Chem., 2008, 283, 30112-30120

65) C. Unverzagt, S. Eller, S. Mezzato, R. Schuberth, A Double Regio and Steroselective Glycosylation Strategy for the Synthesis of N-Glycans, Chem. Eur. J., 2008, 1304-1311

64) S. Andre, T. Kozar, R. Schuberth, C. Unverzagt , S. Kojima, HJ. Gabius, Substitutions in the N-Glycan Core as Regulators of Biorecognition: The Case of Core-Fucose and Bisecting GlcNAc Moieties, Biochemistry, 2007, 46, 6984-6995

63) S. Eller, R. Schuberth, G. Gundel, J. Seifert und C. Unverzagt, Synthese von pentaantennären N-Glycanen mit Bisecting-GlcNAc und Core-Fucose, Angew. Chem., 2007, 119, 4251-4253, Angew. Chem. Int. Ed., 2007, 46, 4173-4175

62) S. Schramm, K. Dettner, C. Unverzagt, Chemical and enzymatic synthesis of buprestin A and B-bitter acylglucosides from Australian jewel beetles (Coleoptera: Buprestidae), Tetrahedron Lett., 200647, 7741-7743

61) S. Andre, S. Kojima, G. Gundel, R. Russwurm, X. Schratt, C. Unverzagt, H.J. Gabius, „Branching mode in complex-type triantennary N-glycans as regulatory element of their ligand properties“, Biochim. Biophys. Acta., 2006, 1760, 768-82

60) E. I. Park, Y. Mi, C. Unverzagt, H.J. Gabius, J.U. Baenziger, „The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acidalpha2,6GalNAc“, Proc. Natl. Acad. Sci. U S A., 2005, 102, 17125-9

59) S. André, S. Kojima, I. Prahl, M. Lensch, C. Unverzagt, H.-J. Gabius, „Introduction of extended LEC14-type branching into core-fucosylated biantennary N-glycan“, FEBS J., 2005, 272, 1986-98

58) R. Schuberth, C. Unverzagt, „Synthesis of a N-Glycan nonasaccharide of the bisecting type with additional core-fucose“, Tetrahedron Lett., 2005, 46, 4201-4204

57) E. Bedini, C. De Castro, G. Erbs, L. Mangoni, J. M. Dow, M. A. Newman, M. Parrilli, C. Unverzagt, „Structure-Dependent Modulation of a Pathogen Response in Plants by Synthetic O-Antigen Polysaccharides“, J. Am. Chem. Soc., 2005, 127, 2414-2416

56) Stefano Mezzato, Manuela Schaffrath, Carlo Unverzagt, „An Orthogonal Double-Linker Resin Facilitates the Efficient Solid-Phase Synthesis of Complex-Type N-Glycopeptide Thioesters Suitable for Native Chemical Ligation“, Angew. Chem., 2005, 117, 1677-1681, Angew. Chem. Int. Ed., 2005, 44, 1650-1654

54) X. Schratt, C. Unverzagt, „Synthesis of an N-glycan decasaccharide of the hybrid type“, Tetrahedron Lett., 2005, 46, 691-694

53) C. Lorenz, P. Hadwiger, M. John, H. P. Vornlocher, C. Unverzagt, „Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells“, Bioorg. Med. Chem. Lett., 2004, 14, 4975-4977

52) S. Reicheneder, C. Unverzagt, „Synthesis of Dimeric Terpenoyl Glycoside side Chains from Cytotoxic Saponins“, Angew. Chem., 2004, 116, 4459-4457, Angew. Chem. Int. Ed., 2004, 43, 4354-4357

51) U. Jeschke, G. Gundel, H. Müller, D.-U. Richter, A. Streu, V.Briese, I. Mylonas, K. Friese, C. Unverzagt, „N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro“, J. Perinat. Med., 2004, 32, 248-253

50) S. André, C. Unverzagt, S. Kojima, M. Frank, J. Seifert, C. Fink, K. Kayser, C.-W. von der Lieth, H.-J. Gabius, „Determination of modulation of ligand properties of synthetic complex-type biantennary N-glycans by introduction of bisecting GlcNAc in silico, in vitro and in vivo“, Eur. J. Biochem., 2004, 271, 117-134

49) E. Bedini, G. Barone, C. Unverzagt, M. Parrilli, „Synthesis of the pentasaccharide repeating unit of the major O-antigen component from Pseudomonas syringae pv. ribicola NVPPB 1010“, Carbohydr. Res., 2004, 32, 248-253

48) M. Schnabel, B. Römpp, D. Ruckdeschel, C. Unverzagt, „Synthesis of tryptophan N-glucoside“, Tetrahedron Lett., 2004, 45, 295-297

47) H. Weiss, C. Unverzagt, Highly branched Oligosaccharides: a General Strategy for the Synthesis of multiantennary N-Glycans carrying the Bisecting Motif, Angew. Chem., 2003, 115, 4389-4392, Angew. Chem. Int. Ed., 2003, 42, 4261-4263

46) G.Voss, M. Gradzielski, J. Heinze, H. Reinke, C. Unverzagt, Highly soluble and Green Indigo Dyes: 4,4´,7,7`-Tetraalkoxy-5,5`-diaminoindigotins, Helv. Chim. Acta, 2003, 86, 1982-2004

45) C. Unverzagt, Synthesis of a Core Trisaccharide as a Versatile Building Block for N-Glycans and Glycoconjugates, Chem. Eur. J., 2003, 9, 1369-1376

44) E. Bedini, M. Parrilli and C. Unverzagt, Oligomerization of a rhamnanic trisaccharide repeating unit of O-chain polysaccharides from phytopathogenic bacteria, Tetrahedron Lett., 2002, 43, 8879-8882

43) I. Prahl, C. Unverzagt, „Enzymatic elongation of the LEC14 Antigen Generates a novel ß-1,2 Arm on N-Glycans“, Angew. Chem., 2002, 114, 4434-4437, Angew. Chem. Int. Ed. Engl.2002, 114, 4259-4262

42) Daniel Varón, Eduardo Lioy, Manuel E. Patarroyo, Xaver Schratt and Carlo Unverzagt, Synthesis of Mannosyl and Oligomannosyl Threonine Building Blocks Found on the Mycobacterium tuberculosis 45 kDa MPT 32 Glycoprotein, Aust. J. Chem., 2002, 55, 161

41) C. Unverzagt, J. Seifert, S. André, S. Kojima, C. Fink, G. Srikrishna, H. Freeze, K. Kayser and H.-J. Gabius, Structure-Activity Profiles of Complex Biantennary Glycans with Core Fucosylation and with/without Additional a2,3/a2,6 Sialylation: Synthesis of Neoglycoproteins and Their Performance in Lectin Assays, Cell Binding and Organ Uptake, J. Med. Chem., 2002, 45, 478-491

40) J. Peter, C. Unverzagt, T. N. Krogh, O. Vorm and W. Hoesel, Identification of pro forms of free prostate specific antigen (F-PSA) from serum of prostate cancer patients by immunosorption and mass spectrometry, Cancer Res., 2001, 61, 957-962

39) I. Prahl and C. Unverzagt, Synthesis of a LEC14 nonasaccharide, a core-fucosylated, biantennary N-glycan with a novel GlcNAc residue in the core region, Tetrahedron Lett., 2000, 41, 10189-10193

38) G. Kuznik, C. Unverzagt, B. Hörsch, G. Kretzschmar, Chemical and enzymatic Synthesis of Modified Sialyl Lewis X Tetrasaccharides with High Affinity for E- and P-Selectin, J. Prakt. Chem., 2000, 342, 745-752

37) C. Unverzagt and J. Seifert, Chemoenzymatic synthesis of deca and dodecasaccharide N-glycans of the 'bisecting' type, Tetrahedron Lett., 2000, 41, 4549-4553

36) J. Peter, C. Unverzagt and W. Hoesel, Analysis of Prostate-Specific Antigen (PSA) after Chemical Release from the Complex with a1-Antichymotrypsin (PSA-ACT), Clin. Chem., 2000, 46, 474-482

35) H.-J. Gabius, N. V. Bovin, U. Brinck, S. Gabius, C. Unverzagt, K. Kayser, Carrier-immobilized Carbohydrate Ligands: Design of the Lectin-Detecting Tools and their Clinical Applications with Focus on Histopathology, in: Lectins and Pathology (Eds: M. Caron and A.-P. Seve) Harwood Academic Publishers, 2000, 01.05.1934

34) J. Peter, C. Unverzagt, H. Lenz and W. Hoesel, Purification of Prostate-Specific Antigen from Human Serum by indirect Immunosorption and Elution with a Hapten, Analytical Biochem., 1999, 273, 98-104

33) C. Unverzagt, Chemical and Enzymatic Synthesis of a Sialylated Biantennary N-Glycan linked to Asparagine, Carbohydr. Res., 1998, 305, 423-431

32) H.-J. Gabius, C. Unverzagt and K. Kayser, Beyond Plant Lectin Histochemistry: Preparation and Application of Markers to visualize the Cellular Capacity for Protein-Carbohydrate Recognition, Biotechnic & Histochemistry, 1998, 73, 263-277

31) J. Peter, C. Unverzagt, W.-D. Engel, D. Renauer, C. Seidel, W. Hösel, Identification of Carbohydrate Deficient Transferrin Forms by MALDI-TOF and  Lectin Elisa, Biochem. Biophys. Acta, 1998, 1380, 93-101

30) C. Unverzagt, „Trends: Organische Chemie-Kohlenhydratchemie 1997“, Nachr. Chem. Tech. Lab., 1998, 46, 163-166

29) S. André, C. Unverzagt, S. Kojima, X. Dong, C. Fink, K. Kayser, H.-J. Gabius, “Neoglycoproteins with the Synthetic Complex Biantennary Nonasaccharide or its a2,3/a2,6-Sialylated Derivatives: Their Preparation, Assessment of their Ligand Properties for Purified Lectins, for Tumor Cells in vitro and in Tissue Sections and their Biodistribution in Tumor-Bearing Mice“, Bioconjugate Chem., 1997, 8, 845-855

28) J. Seifert, C. Unverzagt, “Synthesis of three Biantennary N-Glycans containing the a-1,6-Core-Fucosyl Motif“, Tetrahedron Lett., 1997, 38, 7857-7860

27) C. Unverzagt, “A Modular System for the Synthesis of Complex N-Glycans“, Angew. Chem., 1997, 109, 2078-2081, Angew. Chem. Int. Ed. Engl., 1997, 36, 1989-1992

26) C. Unverzagt, “Building Blocks for Glycoproteins: Synthesis of the Ribonuclease B Fragment 21-25 containing  an Undecasaccharide N-Glycan“, Tetrahedron Lett., 1997, 38, 5627-5630

25) G. Kuznik, B. Hörsch, G. Kretzschmar, C. Unverzagt, "Chemical and enzymatic Synthesis of high-Affinity Ligands for E- and P-Selectin", Bioorg. Med. Chem. Lett., 1997, 5, 577-580

24) C. Unverzagt, “Chemoenzymatic Synthesis of a Sialylated Undecasaccharide-Asparagine“, Angew. Chem., 1996, 108, 2507-2510, Angewandte Chemie Intl. Ed. Engl., 1996, 35, 25350-2353

23) C. Unverzagt, “Chemoenzymatic Synthesis of the fully glycosylated Ribonuclease Fragment 57-61“, Y. Shimonishi (Ed.), Proceedings of the 6th Akabori Conference, German-Japanese Symposium on Peptide Chemistry, 1996, 36-39

22) J. Seifert, C. Unverzagt, “Synthesis of a Core-Fucosylated, Branched  Octasaccharide as a Precursor for Glycopeptides of Complex N-Glycans“, Tetrahedron Lett., 1996, 37, 6537-6530

21) C. Unverzagt, “Transaminations and miscellaneous reactions“, in: Enzyme Catalysis  in Organic Synthesis (Eds: K. Drauz and H. Waldmann), VCH, Weinheim, 1995, 470-480

20) C. Unverzagt, “Chemistry of b-lactams“ , in: Enzyme Catalysis in Organic Synthesis (Eds: K. Drauz and H. Waldmann), VCH, Weinheim, 1995, 458-470

19) C. Unverzagt, H. Kunz, Synthesis of Glycopeptides and Neoglycoproteins containing the fucosylated linkage region of N-Glycoproteins, Bioorg. Med. Chem., 1994, 2, 1189-1201

18) C. Unverzagt, Synthesis of a Biantennary Heptasaccharide by Regioselective Glycosylations, Angew. Chem., 1994, 106, 1170-1173, Angew. Chem. Int. Ed. Engl., 1994, 33, 1102-1104

17) C. Unverzagt, S. Kelm, J. C. Paulson, Chemical and enzymatic Synthesis of multivalent Sialoglycopeptides, Carbohydr. Res., 1994, 251, 285-301

16) H. Kunz, K. von dem Bruch, C. Unverzagt, W. Kosch, “Synthesis of glycopeptides: a challenge for chemical selectivity“, R. S. Hodges, J. A. Smith (Eds.) Pept.: Chem., Struct. Biol., 1994, Proceedings of the 13th American Peptide Symposium, Escom Leiden., 321-323

15) H. Kunz, C. Unverzagt, B. Dombo, W. Kosch, H. Waldmann, “Synthesis of glycopeptide partial structures of virus coat glycoproteins“, Chem. Pept. Proteins, 1993, 5/6(Pt. A), 81-89

14) C. Unverzagt, Got the Flu? Try a Designer Agent Derived from a Sugar, Angew. Chem., 1993, 105, 1762-1764, Angew. Chem. Int. Ed. Engl., 1993, 32, 1691-1693

13) A. Geyer, D. F. Mierke, C. Unverzagt, H. Kessler, Synthesis of cyclic  thiohexapeptides, Peptides, 1992, C. H. Schneider, A. N. Eberle (Eds.), Proceedings of the Twenty-Second European Peptide Symposium, Escom Leiden, 599-600

12) C. Unverzagt, A. Geyer, H. Kessler, Chain Elongation of Thiodipeptides with Proteases, Angew. Chem., 1992, 104, 1231-1233, Angew. Chem. Int. Ed. Engl., 1992, 31, 1229-1230

11) H. Kunz, W. Kosch, J. März, M. Ciommer, W. Guenther, C. Unverzagt, “Synthesis of glycopeptides in solution and on solid phases“, R. Epton (Ed.), Innovation Perspect. Solid Phase Synth. Collect. Pap., Int. Symp., 2nd, Meeting, 1991, Editor(s):, Roger. Intercept: Andover, 1992, 171-178

10) C. Unverzagt, H. Kunz, Stereoselective Synthesis of Glycosides and anomeric Azides of Glucosamine, J. Prakt. Chem., 1992, 334, 570-578

9) H. Kunz, C. Unverzagt, Synthesis of a-Fucosyl Glycosides and Disaccharides using 4-Methoxybenzyl (Mpm) protected Fucosyl Donors, J. Prakt. Chem., 1992, 334, 579-583

8) C. Unverzagt, H. Kunz and J. C. Paulson, High Efficiency Synthesis of  Sialyloligosaccharides and Sialoglycopeptides, J. Am. Chem. Soc., 1990, 112, 39308-9309

7) H. Kunz, C. Unverzagt, Synthesis of Glycopeptides related to the Core Regions of  N-Glycoproteins, E. Wünsch (Ed.), Proceedings of the 3rd Akabori Conference, German-Japanese Symposium on Peptide Chemistry, 1989, 54-58

6) H. Kunz, C. Unverzagt, Protecting-Group-Dependent Stability of Intersaccharide Bonds-Synthesis of a Fucosyl-Chitobiose Glycopeptide, Angew. Chem., 1988, 100, 1763-1765, Angew. Chem. Int. Ed. Engl., 1988, 27, 1697

5) H. Kunz, S. Friedrich-Bochnitschek, S. Birnbach and C. Unverzagt, Synthesis of Glycopeptides with Tn- and T-Antigen Structure using New Protecting Techniques, Peptide Chemistry, 1987, T. Shiba & S. Sakakibara (Ed.), Protein Research Foundation, Osaka, 1988, 323-326

4) Review: C. Unverzagt, H. Kunz, Synthesis of Glycopeptide Partial Structures of Glycoproteins - a Challenge for selective protecting Group Techniques, GIT Fachzeitschrift für das Laboratorium, 1988, 6, 599-604

3) H. Kunz, H. Waldmann, C. Unverzagt, Synthesis of Glycopeptides using the Allyl Ester and the Allyloxycarbonyl Group as protecting Functions, Peptides, 1986, Editor: D. Theodoropoulos, Walter de Gruyter& Co. Berlin, 1987, 615-618

2) H. Kunz, H. Waldmann, C. Unverzagt, Allylester as temporary protecting group for the b-carboxy function of aspartic acid, Int J. Pept. Prot. Res., 1987, 26, 493

1) H. Kunz, C. Unverzagt, The Allyloxycarbonyl (Aloc) Moiety-Conversion of an Unsuitable into a Valuable Protecting Group for Peptide Synthesis, Angew. Chem., 1984, 96, 426-427, Angew. Chem. Int. Ed. Engl., 1984, 23, 436-437

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